Антибактеріальні властивості озонвмісних препаратів у лікуванні корів та кіз із гонадо- та метропатіями

Abstract

Встановлено, що використання озонвмісних препаратів “ОКО” та “Прозон” у лікуванні корів та кіз із гонадо- та метропатіями забезпечує високу ефективність та економічну вигоду за позитивного впливу на організм тварин і відсутності побічних ефектів. Застосування озоно- та прополістерапії за лікування корів та кіз із гострим післяродовим катарально-гнійним ендометритом і діорганною патологією (гіполютеоліз ↔ субклінічний ендометрит) дозволяє не лише усунути клінічні ознаки захворювань (скорочення тривалості періодів терапії та прояву еструму і підвищення заплідненості), а й повне виліковування тварин, підтверджене результатами цитологічного дослідження цервікальних мазків. The antibacterial properties of ozone-containing preparations for the treatment of cows and goats with gonado- and metropathology have been studied. It has been established that the drugs “OKO” and “Prozon” form the basis of ozone and propolistherapy, provide high efficiency and economic benefits for positive effects on the organism of animals and the absence of side effects. Treatment of cows and goats with acute postnatal catarrhal purulent endometritis was carried out according to a purposeful program, which is motivated by the principle of the action of the drugs. The program of antibiotic, nitrofuran and sulfanilamidotherapy replaced with the use of ozone-containing preparations “OKO” and “Prozon”. The results of the clinical evaluation indicate that the method of treating cows and goats using ozone-containing preparations has a high therapeutic efficacy. Thus, in experimental animals, the duration of the treatment period decreased by 1,1‒5,4 days compared with control, the period of the period from birth to live was reduced by 4,5‒15,3 days, and fertility increased by 9,1‒54,7 %. Comprehensive therapy of cows and goats with divergent pathology (hypoluteolysis↔subclinical endometritis) was carried out according to the program, which provides the final alternative: a) recovery with the restoration of the morpho-functional state of the endometrium; b) prophylactic therapy of cows with hypoluteolysis (delayed regression of the yellow body). The program “use of antibacterial drugs” has been replaced by ozone-containing preparations “OKO” and “Prozon”. It was established that compared with the control in experimental animals, the duration of treatment periods (for 1,6‒6,1 days) and the manifestation of acute after treatment (by 4,5‒12,6, fertility increased (by 21,4‒47,1 %). Due to the fact that the clinical recovery does not always indicate a complete cure, we conducted its control by conducting light optic and luminescent methods of cytological examination of cervical smears. The obtained data indicate positive changes in the characteristics of cervical smear and, accordingly, the effectiveness of ozone-containing preparations and their antibacterial properties. In particular, the number of epithelial cells and leukocytes decreased (by 19,6 or 64,7 %), as well as microbes (by 47,1 or 80,2 %) and cells with yellow-red coloration (by 6,2 % or 73,7 %) Positive is the dynamics of the ratio of the number of epithelial cells and leukocytes and epitheliocytes (from 1:3 to 1:1) with normal structure and dystrophy (from 1:3 to 2,5:1), as well as an increase in cells with a green color (3,8 or 102,9 %).