Ефективність комплексного лікування у собак за гепаторенального синдрому

Abstract

Визначена терапевтична ефективність комплексного лікування у собак за гепаторенального синдрому. Встановлена позитивна динаміка біохімічних показників крові у собак за гепаторенального синдрому, особливо каталітична активність органоспецифічних ферментів, за комбінованої терапії із застосуванням препаратів гепатопротекторної дії (глутаргін, гепатоджект) та нефропротекторів (канефрон) у комплексі з регідратаційною терапією та протимікробними (ампіцилін) засобами. Determined therapeutic efficiency comprehensive treatment for dogs hepatorenalnoho syndrome. The positive dynamics of blood biochemical parameters in dogs for hepatorenal syndrome, especially organ catalytic activity of enzymes by combination therapy using drugs hepatoprotective effect (glutargin, Hepatojekt) and nephroprotective (Canephron) in combination with rehydration therapy and antimicrobial (ampicillin) means. Studies conducted over the years in 2014-2017 veterinary clinic "Biosvit" Dnipro city. This was selected 10 dogs with symptoms of hepatorenal syndrome. The content of total protein in serum of patients dogs was in the range of 67 to 98 g / l. hyperproteinemia set at 5 with 10 dogs. The activity of AST in the blood of dogs was in the range of 51 to 96 U / l, ALT from 57 to 85 U / l. The increased activity of enzymes found in the blood of 100% of the dogs. Total bilirubin content in the serum of patients with dogs was in the range of 2 to 12.3 mmol / l, in particular indirect bilirubin from 1.7 to 10.5 mmol / L, direct bilirubin of 0.2 to 3.5 mmol / l. Hyperbilirubinemia installed in 7 of 10 dogs. The content of urea in the blood of dogs was in the range of 8.7 to 21.3 mmol/L. All dogs found an increase in serum creatinine – from 137 to 239 mmol/l. After treatment decreased the total protein in serum of dogs 10 g / l (p <0.05), activity of AST and ALT in blood serum of dogs, respectively, 25.4 and 29.3 U/L (p <0.001), total serum bilirubin in dogs of 3.7 mmol / L (p <0.05), including indirect bilirubin of 3.2 mmol / L (p <0.05), urea content in blood serum of dogs decrease by 3.8 mmol / L (p <0.05) in 80% of animal sits content was within normal limits. The content of creatinine in the blood serum of dogs afte retreatment 54.9 mmol / l (p <0.001) in allanimalsits content was within normal limits. The used complex therapy, including hepatoprotectors (glutargin and Hepatojekt) and nephroprotectors (Canephron) positively affected the recovery of liver function and kidney hepatorenal syndrome in dogs. In the treatment decreased the content of serum total protein dogs, bilirubin, AST and ALT activity, urea and creatinine.